Yeah,
I haven't done this, but I think you should be able to do get_overlapping_bodies()
in your Area2D script
(returns a list of the bodies in the area). So something like:
func _ready()
for body in self.get_overlapping_bodies():
body.queue_free()
This assumes that you have collision shapes on the tiles and that they are on a collision layer that the Area2D interacts with.