So for the record, that worked. Here's the commands:
so if the texture is on the NODE, you would use:
$sphere.get_surface_material(0).set("shader_param/AlphaKnob", 0.5)
and if the texture is on the MESH, (like it is when it comes over from Blender via gLTF2), you would use:
$sphere.mesh.surface_get_material(0).set("shader_param/AlphaKnob", 0.5)
Also note that the commands are different depending on whether the texture is on the mesh or on the node. The "0" in both cases refers to the material in that slot, so if you have materials 0,1,2 etc., you're referencing the correct one (but if you only have one material, it's 0.