You could define setget functions for your variable:
Inside those functions you return or set the value of the global variable.
If you are adressing the contents of complex data types (dictionaries, objects, arrays) you can also assign that variable to a local var which then (always) receives a kind of pointer.
So if you define a dictionary in scene:
var my_settings = {"audio_volume":0.5, "cheat": false}
Then you could copy that dictionary “pointer” to a local var and use that instead:
var glb_settings = scene.my_settings
glb_settings["audio_volume"] = 0.75
print("cheat is: "+str(glb_settings["cheat"]))
Although all this is not very “transparent” and may be difficult to understand if you (or someone else) looks at the code at a later time. So I opt for just referencing the global singleton. (i.e. scene.example).