Be aware that saving the ProjectSettings (so that they are automatically loaded on next start) might not work on Android/iOS as they don't allow writing in res:// from where the settings are usually loaded.
To stay on topic:
Depending on the game, you can also change the max distance of shadows on lights (may be set it to 0 on very slow machines).
You can also change the ViewRange of the Camera.
And you can scale the viewport to run the game i.e. at half resolution.
(You'd have to scane the gui accordingly.)
These can be set/changed at runtime.